Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5718315 | 0.91 | SLC6A2 (0.44) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL5701109 | 0.90 | SLC6A2 (0.43) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL5718197 | 0.87 | SLC6A2 (0.53) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL898940 | 0.85 | SLC6A2 (0.49) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL898941 | 0.85 | SLC6A2 (0.49) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL28002157 | 0.84 | SLC6A4 (0.47) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL13292259 | 0.83 | SLC6A4 (0.74) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL13292251 | 0.83 | SLC6A2 (0.55) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL12298854 | 0.83 | SLC6A4 (0.74) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL15216759 | 0.83 | SLC6A4 (0.74) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345096-B2 | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms | WYETH (US) | 2008-03-18 | — | — | US | disclosed |
| EP-1687288-A1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005037809-A1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |