Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.74 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12298854 | 1.00 | SLC6A4 (0.74) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 | |
| SCHEMBL13292259 | 1.00 | SLC6A4 (0.74) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 | |
| SCHEMBL19980789 | 0.86 | SLC6A4 (0.70) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 | |
| SCHEMBL5391759 | 0.86 | SLC6A4 (0.70) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 | |
| SCHEMBL13292251 | 0.86 | SLC6A2 (0.55) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 | |
| SCHEMBL15127705 | 0.86 | SLC6A4 (0.70) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 | |
| O-Desmethyl Tramadol SCHEMBL13948071 | 0.85 | OPRM1 (0.77) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 | |
| SCHEMBL13950721 | 0.85 | SLC22A1 (0.72) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 | |
| Desmetramadol SCHEMBL57246 | 0.85 | OPRM1 (1.00) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 | |
| O-Desmethyl Tramadol SCHEMBL4396389 | 0.85 | OPRM1 (1.00) | SLC6A4OPRM1SLC6A2OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716306-B2 | Carboxamide bioisosteres of opiates | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2014-05-06 | — | — | US | disclosed |
| US-20130225628-A1 | CARBOXAMIDE BIOISOSTERES OF OPIATES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225628-A1 | CARBOXAMIDE BIOISOSTERES OF OPIATES | OPRK1, OPRD1, OPRM1 | SLC6A4 1325/4885OPRM1 3/4885SLC6A2 1448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.