Thioproperazine

Thioproperazine

SCHEMBL49902

CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD3 P35462 7/20 1.00
DRD2 P14416 7/20 1.00
HRH1 P35367 7/20 1.00
HTR1A P08908 6/20 1.00
ADRA2A P08913 6/20 1.00
DRD1 P21728 6/20 1.00
ADRA1A P35348 6/20 1.00
SLC6A3 Q01959 6/20 1.00
KCNH2 Q12809 6/20 1.00
CHRM1 P11229 5/20 1.00
SLC6A2 P23975 5/20 1.00
ADRA2C P18825 5/20 1.00
HTR2A P28223 5/20 1.00
CHRM2 P08172 4/20 1.00
OPRM1 P35372 4/20 1.00
SLC6A4 P31645 4/20 1.00
ADRA2B P18089 4/20 1.00
HTR2C P28335 4/20 1.00
PDE4D Q08499 4/20 1.00
TBXA2R P21731 3/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thioproperazine SCHEMBL29394708 1.00 DRD3 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL29372322 1.00 DRD3 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL2386850 0.96 CYP3A4 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL3027811 0.96 CYP3A4 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL29888916 0.96 CYP3A4 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL11047989 0.93 DRD3 (0.86) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL11047988 0.93 DRD3 (0.86) DRD3DRD2HRH1HTR1AADRA2A
SCHEMBL6946497 0.92 DRD3 (0.85) DRD3DRD2HRH1HTR1AADRA2A
SCHEMBL10136896 0.92 DRD2 (0.85) DRD3DRD2HRH1HTR1AADRA2A
SCHEMBL10136877 0.92 DRD3 (0.85) DRD3DRD2HRH1HTR1AADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3334 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12527754-B2 Methods and compositions for preventing and treating metabolic syndrome induced by antipsychotic treatment and related diseases and conditions TUFTS MEDICAL CENTER, INC. (US) 2026-01-20 US claimed
EP-4618973-A1 METHODS OF SWITCHING NEUROPSYCHIATRIC MEDICATIONS USING ULOTARONT Sumitomo Pharma America, Inc. (US) 2025-09-24 EP claimed
US-20250179064-A1 BENZOQUINOLONE INHIBITORS OF VMAT2 AUSPEX PHARMACEUTICALS LLC 2025-06-05 US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
WO-2025101418-A1 TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS IN PATIENTS WITH PROMINENT ANHEDONIA USING IRDABISANT AS A MONOTHERAPY OR IN COMBINATION WITH AN ANTIPSYCHOTIC AGENT ALTO NEUROSCIENCE, INC. (US) 2025-05-15 WO claimed
US-20250144092-A1 TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS IN PATIENTS WITH PROMINENT ANHEDONIA USING IRDABISANT AS A MONOTHERAPY OR IN COMBINATION WITH AN ANTIPSYCHOTIC AGENT ALTO NEUROSCIENCE, INC. 2025-05-08 US claimed
US-20240261236-A1 METHODS OF USING NMDA RECEPTOR ANTAGONISTS SEELOS THERAPEUTICS, INC. 2024-08-08 US claimed
WO-2024107681-A1 METHODS OF SWITCHING NEUROPSYCHIATRIC MEDICATIONS USING ULOTARONT SUMITOMO PHARMA AMERICA, INC. (US) 2024-05-23 WO claimed
WO-2024028611-A1 OXADIAZOLE COMPOUNDS FOR USE IN THE TREATMENT OF OBSESSIVE COMPULSIVE DISORDER SIRGARTAN HOLDINGS LTD (GB) 2024-02-08 WO claimed
US-20240000810-A1 USE OF CANNABINOIDS IN THE TREATMENT OF TOURETTE SYNDROME AND TIC DISORDERS Orcosa Inc. (US) 2024-01-04 US claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-1005651-A1 METHODS OF IDENTIFYING BIOLOGICAL AGENT COMPOSITIONS SUPRATEK PHARMA, INC. (CA) 2000-06-07 EP claimed
CN-1251526-A New therapeutic combinations of mirtazapine and antipsychotic agents, for treatment of prophylaxis of psychotic disorders AKZO NOBEL NV (NL) 2000-04-26 CN claimed
EP-0969845-A1 NEW THERAPEUTIC COMBINATIONS OF MIRTAZAPINE AND ANTIPSYCHOTIC AGENTS, FOR THE TREATMENT OR PROPHYLAXIS OF PSYCHOTIC DISORDERS Akzo Nobel N.V. (NL) 2000-01-12 EP claimed
WO-1999008112-A1 METHODS OF IDENTIFYING BIOLOGICAL AGENT COMPOSITIONS SUPRATEK PHARMA INC. (CA) 1999-02-18 WO claimed
WO-1998043646-A1 NEW THERAPEUTIC COMBINATIONS OF MIRTAZAPINE AND ANTIPSYCHOTIC AGENTS, FOR THE TREATMENT OR PROPHYLAXIS OF PSYCHOTIC DISORDERS AKZO NOBEL N.V. (NL) 1998-10-08 WO claimed
WO-1996001631-A1 NOVEL COMBINATION PRODUCT COMPRISING CAPRIPRAMINE AND A NEUROLEPTIC PIERRE FABRE MEDICAMENT (FR) 1996-01-25 WO claimed
EP-0180364-B1 PHARMACEUTICAL COMPOSITIONS CONTAINING PHENOTHIAZINES RECKITT AND COLMAN PRODUCTS LIMITED (GB) 1990-03-07 EP claimed
EP-0180364-A2 Pharmaceutical compositions containing phenothiazines RECKITT AND COLMAN PRODUCTS LIMITED (GB) 1986-05-07 EP claimed
US-4175119-A Composition and method to prevent accidental and intentional overdosage with psychoactive drugs PORTER GARRY L 1979-11-20 US claimed