Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Thioproperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.86 |
| ▸ | HRH1 known ✓ | P35367 | 8/20 | 0.86 |
| ▸ | HTR1A known ✓ | P08908 | 7/20 | 0.86 |
| ▸ | ADRA2A known ✓ | P08913 | 7/20 | 0.86 |
| ▸ | DRD1 known ✓ | P21728 | 7/20 | 0.86 |
| ▸ | ADRA1A known ✓ | P35348 | 7/20 | 0.86 |
| ▸ | SLC6A3 known ✓ | Q01959 | 7/20 | 0.86 |
| ▸ | KCNH2 known ✓ | Q12809 | 7/20 | 0.86 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.86 |
| ▸ | ADRA2C known ✓ | P18825 | 6/20 | 0.86 |
| ▸ | HTR2A known ✓ | P28223 | 6/20 | 0.86 |
| ▸ | ADRA2B known ✓ | P18089 | 5/20 | 0.86 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.86 |
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.86 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.86 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 4/20 | 0.86 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.86 |
| ▸ | MEN1 known ✓ | O00255 | 5/20 | 0.71 |
| ▸ | KMT2A known ✓ | Q03164 | 5/20 | 0.71 |
| ▸ | HTR2B known ✓ | P41595 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioproperazine SCHEMBL11047988 | 1.00 | DRD3 (0.86) | DRD3DRD2HRH1HTR1AADRA2A | |
| Thioproperazine SCHEMBL49902 | 0.93 | DRD3 (1.00) | DRD3DRD2HRH1HTR1AADRA2A | |
| Thioproperazine SCHEMBL29372322 | 0.93 | DRD3 (1.00) | DRD3DRD2HRH1HTR1AADRA2A | |
| Thioproperazine SCHEMBL29394708 | 0.93 | DRD3 (1.00) | DRD3DRD2HRH1HTR1AADRA2A | |
| Thioproperazine SCHEMBL29888916 | 0.91 | CYP3A4 (1.00) | DRD3DRD2HRH1HTR1AADRA2A | |
| Thioproperazine SCHEMBL3027811 | 0.91 | CYP3A4 (1.00) | DRD3DRD2HRH1HTR1AADRA2A | |
| Thioproperazine SCHEMBL2386850 | 0.91 | CYP3A4 (1.00) | DRD3DRD2HRH1HTR1AADRA2A | |
| SCHEMBL6946497 | 0.87 | DRD3 (0.85) | DRD3DRD2HRH1HTR1AADRA2A | |
| Perazine SCHEMBL220704 | 0.86 | MAPT (0.82) | DRD3DRD2HRH1HTR1AADRA2A | |
| Perazine SCHEMBL220703 | 0.86 | MAPT (0.82) | DRD3DRD2HRH1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4484921-A | Theophylline therapy utilizing osmotic delivery | ALZA CORPORATION (US) | 1984-11-27 | — | — | US | disclosed |
| US-4439195-A | Theophylline therapy | ALZA CORPORATION (US) | 1984-03-27 | — | — | US | disclosed |
| US-4326525-A | Osmotic device that improves delivery properties of agent in situ | ALZA CORPORATION (US) | 1982-04-27 | — | — | US | disclosed |