Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13936520 | 1.00 | BDKRB1 (1.00) | BDKRB1CYP3A4 | |
| SCHEMBL4958257 | 1.00 | BDKRB1 (1.00) | BDKRB1CYP3A4 | |
| SCHEMBL4958632 | 0.94 | BDKRB1 (0.89) | BDKRB1CYP3A4 | |
| SCHEMBL4959111 | 0.94 | BDKRB1 (0.88) | BDKRB1CYP3A4 | |
| SCHEMBL4957954 | 0.93 | BDKRB1 (1.00) | BDKRB1CYP3A4 | |
| SCHEMBL4522240 | 0.93 | BDKRB1 (1.00) | BDKRB1CYP3A4 | |
| SCHEMBL13955195 | 0.93 | BDKRB1 (1.00) | BDKRB1CYP3A4 | |
| SCHEMBL4957055 | 0.92 | BDKRB1 (1.00) | BDKRB1CYP3A4 | |
| SCHEMBL4957994 | 0.92 | BDKRB1 (0.86) | BDKRB1CYP3A4 | |
| SCHEMBL4958197 | 0.91 | BDKRB1 (0.85) | BDKRB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393852-B2 | Piperazine derivatives and methods of use | AMGEN INC. (US) | 2008-07-01 | — | — | US | claimed |
| US-20090054460-A1 | Piperazine derivatives and methods of use | CHEN JIAN J | 2009-02-26 | — | — | US | disclosed |
| US-7393852-B2 | Piperazine derivatives and methods of use | AMGEN INC. (US) | 2008-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054460-A1 | Piperazine derivatives and methods of use | PTGES, PTGES2, PTGIS | BDKRB1 259/4885CYP3A4 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.