Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4718572 | 1.00 | MAPKAPK2 (0.54) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| SCHEMBL14188320 | 0.94 | MAPKAPK2 (0.59) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| SCHEMBL27619923 | 0.87 | MAPKAPK2 (0.45) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| SCHEMBL4718569 | 0.87 | MAPKAPK2 (0.45) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| SCHEMBL14188346 | 0.82 | POLB (0.50) | MAPKAPK2KDM4EALDH1A1HPGDPOLB | |
| Hydrochloric Acid SCHEMBL4994467 | 0.81 | POLB (0.49) | MAPKAPK2KDM4EALDH1A1HPGDPOLB | |
| Hydrochloric Acid SCHEMBL4716063 | 0.81 | POLB (0.49) | MAPKAPK2KDM4EALDH1A1HPGDPOLB | |
| Trifluoroacetic Acid SCHEMBL4993386 | 0.81 | HTR5A (0.36) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| Trifluoroacetic Acid SCHEMBL4993407 | 0.81 | HTR5A (0.36) | MAPKAPK2CDC7PLK4CHEK1IKBKB | |
| Trifluoroacetic Acid SCHEMBL4718586 | 0.79 | MAPKAPK2 (0.52) | MAPKAPK2JAK2JAK3MARS1GRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1747949-A | Acyclic pyrazole compounds | PHARMACIA CORP (US) | 2006-03-15 | — | — | CN | claimed |
| US-20040152739-A1 | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-08-05 | — | — | US | claimed |
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| US-20040152739-A1 | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | MAPKAPK2 2/4885CDC7 487/4885PLK4 576/4885 |
| US-20040152739-A1 | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MAPKAPK2, MAP3K2, MAP4K2 | MAPKAPK2 1/4885CDC7 331/4885PLK4 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.