Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.36 |
| ▸ | GRN | P28799 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.32 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.32 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.32 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4993407 | 1.00 | HTR5A (0.36) | HTR5AHTR1ADRD2DRD4HTR1D | |
| SCHEMBL14188295 | 0.95 | MAPKAPK2 (0.39) | MAPKAPK2GRNSORT1PLAAT3PLAAT5 | |
| SCHEMBL4993397 | 0.90 | HTR5A (0.32) | HTR5AHTR1ADRD2DRD4HTR1D | |
| SCHEMBL4997314 | 0.86 | SMN1; SMN2 (0.43) | MAPKAPK2MEN1MAPTKMT2A | |
| SCHEMBL4997308 | 0.86 | SMN1; SMN2 (0.43) | MAPKAPK2MEN1MAPTKMT2A | |
| Trifluoroacetic Acid SCHEMBL4991464 | 0.81 | MAPKAPK2 (0.54) | MAPKAPK2GRNSORT1MAPK1MAPT | |
| Trifluoroacetic Acid SCHEMBL4718572 | 0.81 | MAPKAPK2 (0.54) | MAPKAPK2GRNSORT1MAPK1MAPT | |
| SCHEMBL14188401 | 0.79 | MARS1 (0.42) | MAPKAPK2GRNSORT1MAPTHDAC3 | |
| Hydrochloric Acid SCHEMBL4713505 | 0.78 | MARS1 (0.42) | MAPKAPK2GRNSORT1MAPTHDAC3 | |
| SCHEMBL14188320 | 0.75 | MAPKAPK2 (0.59) | MAPKAPK2MAPK1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| US-20040152739-A1 | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | HTR5A 2937/4885HTR1A 3754/4885DRD2 4306/4885 |
| US-20040152739-A1 | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MAPKAPK2, MAP3K2, MAP4K2 | HTR5A 2334/4885HTR1A 3015/4885DRD2 3916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.