Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | F10 | P00742 | 6/20 | 0.42 |
| ▸ | F7 | P08709 | 6/20 | 0.42 |
| ▸ | F3 | P13726 | 6/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 4/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4986341 | 0.87 | AKR1C3 (0.43) | PTGS2AKR1C3AKR1C2FFAR1RXRA | |
| SCHEMBL4989998 | 0.87 | PTGS2 (0.46) | PTGS2AKR1C3AKR1C2FFAR1L3MBTL1 | |
| SCHEMBL4988083 | 0.86 | AKR1C3 (0.45) | PTGS2AKR1C3AKR1C2FFAR1PARP10 | |
| SCHEMBL4984353 | 0.84 | PTGS2 (0.48) | PTGS2F10F7F3PRSS1 | |
| SCHEMBL4986175 | 0.84 | PTGS2 (0.39) | PTGS2F10F7F3PRSS1 | |
| SCHEMBL27643882 | 0.83 | PTGS2 (0.46) | PTGS2F10F7F3PRSS1 | |
| SCHEMBL4989823 | 0.83 | PPARG (0.41) | PTGS2AKR1C3AKR1C2PPARGPPARD | |
| SCHEMBL4986555 | 0.82 | PTGS2 (0.46) | PTGS2F10F7F3PRSS1 | |
| SCHEMBL4991370 | 0.81 | TNF (0.42) | PTGS2F10F7F3PRSS1 | |
| SCHEMBL4990974 | 0.81 | AKR1C3 (0.43) | PTGS2AKR1C3AKR1C2FFAR1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124668-A1 | Amino acids with affinity for the alpha2delta-protein | WARNER-LAMBERT COMPANY LLC | 2005-06-09 | — | — | US | claimed |
| US-7388023-B2 | Amino acids with affinity for the α2δ-protein | WARNER-LAMBERT COMPANY LLC (US) | 2008-06-17 | — | — | US | disclosed |
| US-20070129550-A1 | AMINO ACIDS WITH AFFINITY FOR THE ALPHA-2-DELTA-PROTEIN | WANER-LAMBERT COMPANY LLC (US) | 2007-06-07 | — | — | US | disclosed |
| US-7179934-B2 | Amino acids with affinity for the α2δ-protein | WARNER-LAMBERT COMPANY LLC (US) | 2007-02-20 | — | — | US | disclosed |
| US-20050124668-A1 | Amino acids with affinity for the alpha2delta-protein | WARNER-LAMBERT COMPANY LLC | 2005-06-09 | — | — | US | disclosed |
| US-20050101643-A1 | Amino acids with affinity for the alpha2delta-protein | WARNER-LAMBERT COMPANY LLC | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124668-A1 | Amino acids with affinity for the alpha2delta-protein | SCN2A, SCN1A, OPRD1 | PTGS2 1324/4885F10 3141/4885F7 3921/4885 |
| US-20070129550-A1 | AMINO ACIDS WITH AFFINITY FOR THE ALPHA-2-DELTA-PROTEIN | SCN2A, OPRD1, SCN1A | PTGS2 948/4885F10 3009/4885F7 3901/4885 |
| US-20050101643-A1 | Amino acids with affinity for the alpha2delta-protein | SCN2A, OPRD1, SCN1A | PTGS2 1173/4885F10 3107/4885F7 3859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.