Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.57 |
| ▸ | HTR1B | P28222 | 8/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.46 |
| ▸ | PTGIR | P43119 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4994510 | 0.82 | HTR1B (0.53) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL4993062 | 0.82 | HTR1D (0.58) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL4990257 | 0.82 | HTR1D (0.58) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL4993251 | 0.78 | HTR1B (0.48) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL14092041 | 0.77 | HTR1D (0.47) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL957285 | 0.75 | HTR1D (0.73) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Bromide SCHEMBL959007 | 0.74 | HTR1D (0.71) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL953395 | 0.73 | TAAR1 (0.55) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL4992378 | 0.73 | ALDH1A1 (0.61) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL10934485 | 0.73 | HTR1B (0.53) | HTR1DHTR1BADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407980-B2 | Imidazolinylmethyl aralkylsulfonamides | ROCHE PALO ALTO LLC (US) | 2008-08-05 | — | — | US | disclosed |