Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4991829 | 0.87 | CYP11B1 (0.46) | CYP11B1CYP11B2MAPTKDM4EAXL | |
| SCHEMBL4996338 | 0.86 | MAPT (0.49) | CYP11B1CYP11B2ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL4992408 | 0.84 | CYP11B1 (0.44) | CYP11B1CYP11B2ALDH1A1MAPTAXL | |
| SCHEMBL4997778 | 0.83 | PIM1 (0.49) | CYP11B1CYP11B2ALDH1A1HSD17B10KDM4E | |
| SCHEMBL5003458 | 0.83 | PHGDH (0.46) | CYP11B1CYP11B2MAPTAXLRAD52 | |
| SCHEMBL4991687 | 0.83 | CYP11B1 (0.43) | CYP11B1CYP11B2ALDH1A1HSD17B10MAPT | |
| SCHEMBL4995405 | 0.83 | L3MBTL1 (0.46) | CYP11B1CYP11B2ALDH1A1MAPTHPGD | |
| SCHEMBL5003173 | 0.82 | CYP11B1 (0.44) | CYP11B1CYP11B2MAPTKDM4EPHGDH | |
| SCHEMBL5000846 | 0.81 | CYP11B1 (0.47) | CYP11B1CYP11B2MAPTRAD52PIM2 | |
| SCHEMBL5003086 | 0.81 | CYP11B1 (0.47) | CYP11B1CYP11B2AXLRAD52PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | CYP11B1 132/4885CYP11B2 112/4885ALDH1A1 1034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.