Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.35 |
| ▸ | GCGR | P47871 | 3/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4991829 | 0.87 | CYP11B1 (0.46) | CYP11B1CYP11B2PHGDHPIM2PIM1 | |
| SCHEMBL5000656 | 0.86 | MAPT (0.49) | CYP11B1CYP11B2ALDH1A1PIM2PIM1 | |
| SCHEMBL4995356 | 0.84 | CYP11B1 (0.44) | CYP11B1CYP11B2ALDH1A1PHGDHPIM2 | |
| SCHEMBL5002996 | 0.84 | LMNA (0.49) | CYP11B1CYP11B2ALDH1A1L3MBTL1DRD2 | |
| SCHEMBL4997778 | 0.83 | PIM1 (0.49) | CYP11B1CYP11B2ALDH1A1PIM2PIM1 | |
| SCHEMBL5003458 | 0.83 | PHGDH (0.46) | CYP11B1CYP11B2PHGDHPIM2PIM1 | |
| SCHEMBL4995405 | 0.83 | L3MBTL1 (0.46) | CYP11B1CYP11B2ALDH1A1L3MBTL1DYRK1A | |
| SCHEMBL4991687 | 0.83 | CYP11B1 (0.43) | CYP11B1CYP11B2ALDH1A1L3MBTL1AXL | |
| SCHEMBL5003173 | 0.82 | CYP11B1 (0.44) | CYP11B1CYP11B2PHGDHPIM2PIM1 | |
| SCHEMBL5000846 | 0.81 | CYP11B1 (0.47) | CYP11B1CYP11B2PIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | CYP11B1 132/4885CYP11B2 112/4885ALDH1A1 1034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.