SCHEMBL4997683

SCHEMBL4997683

Oc1cccc(O)c1-c1c(Cl)cccc1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.59
ALDH1A1 P00352 8/20 0.57
HSD17B10 Q99714 6/20 0.50
ALOX15 P16050 5/20 0.50
TDP1 Q9NUW8 5/20 0.50
LMNA P02545 4/20 0.50
HPGD P15428 4/20 0.50
RECQL P46063 4/20 0.50
EGFR P00533 2/20 0.50
CA2 P00918 2/20 0.50
FYN P06241 2/20 0.50
MMP9 P14780 2/20 0.50
ADAMTS4 O75173 1/20 0.50
CA1 P00915 1/20 0.50
MMP2 P08253 1/20 0.50
MMP8 P22894 1/20 0.50
CA6 P23280 1/20 0.50
CDK2 P24941 1/20 0.50
MMP12 P39900 1/20 0.50
ADAMTS5 Q9UNA0 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20983402 0.84 HSP90AA1 (0.51) TSHRALDH1A1HSP90AA1MAOATRPA1
SCHEMBL5948479 0.84 TSHR (0.54) TSHRALDH1A1HSD17B10ALOX15TDP1
SCHEMBL9564314 0.84 TSHR (0.48) TSHRALDH1A1HSD17B10ALOX15TDP1
SCHEMBL19802983 0.84 TSHR (0.48) TSHRALDH1A1LMNAHSP90AA1MAPT
SCHEMBL11267122 0.82 TSHR (0.46) TSHRALDH1A1HSD17B10ALOX15TDP1
SCHEMBL5918581 0.82 ALOX15 (0.60) TSHRALDH1A1HSD17B10ALOX15TDP1
SCHEMBL2471569 0.82 TSHR (0.57) TSHRALDH1A1TDP1LMNAHSP90AA1
SCHEMBL1022491 0.80 ALDH1A1 (0.54) TSHRALDH1A1HSD17B10ALOX15TDP1
SCHEMBL8814321 0.80 ALDH1A1 (0.54) TSHRALDH1A1HSD17B10ALOX15TDP1
SCHEMBL4621457 0.80 ALDH1A1 (0.54) TSHRALDH1A1HSD17B10ALOX15TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3681504-B1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN INC (US) 2023-08-23 EP disclosed
US-11573224-B2 Methods of detection using X-ray fluorescence ICAGEN, LLC (US) 2023-02-07 US disclosed
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
US-10877035-B2 Advanced drug development and manufacturing ICAGEN, LLC (US) 2020-12-29 US disclosed
US-20200278346-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ADJACENT ACQUISITION CO., LLC 2020-09-03 US disclosed
EP-3681504-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE Icagen, Inc. (US) 2020-07-22 EP disclosed
US-20190192691-A1 REGULATED BIOCIRCUIT SYSTEMS OBSIDIAN THERAPEUTICS, INC. 2019-06-27 US disclosed
WO-2019055754-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN, INC. (US) 2019-03-21 WO disclosed
US-20150309021-A1 Advanced Drug Development and Manufacturing LOS ALAMOS NATIONAL SECURITY, LLC 2015-10-29 US disclosed
EP-2511844-B1 X-ray microscope XRPRO SCIENCES INC (US) 2015-08-12 EP disclosed
EP-2511844-A2 Advanced drug development and manufacturing Los Alamos National Security, LLC (US) 2012-10-17 EP disclosed
EP-2084519-B1 X-RAY FLUORESCENCE ANALYSIS METHOD LOS ALAMOS NAT SECURITY LLC (US) 2012-08-01 EP disclosed
US-20080220441-A1 Advanced drug development and manufacturing THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2008-09-11 US disclosed