Tavaborole

Tavaborole

SCHEMBL500016

OB1OCc2cc(F)ccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA1 P00915 6/20 1.00
CA2 P00918 6/20 1.00
PDE3A Q14432 2/20 1.00
PDE4B Q07343 12/20 0.69
PDE4A P27815 10/20 0.69
PDE4C Q08493 10/20 0.69
PDE4D Q08499 10/20 0.69
CA12 O43570 4/20 0.50
CA9 Q16790 4/20 0.50
CHRM1 P11229 1/20 0.48
ADRA1A P35348 1/20 0.48
PDE1A P54750 1/20 0.48
PDE3B Q13370 1/20 0.48
PDE7A Q13946 1/20 0.48
CA4 P22748 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tavaborole SCHEMBL596052 1.00 CA1 (1.00) CA1CA2PDE3APDE4BPDE4A
SCHEMBL19171231 1.00 CA1 (1.00) CA1CA2PDE3APDE4BPDE4A
Tavaborole SCHEMBL29372574 1.00 CA1 (1.00) CA1CA2PDE3APDE4BPDE4A
Tavaborole SCHEMBL28132066 0.89 CA1 (0.79) CA1CA2PDE3APDE4BPDE4A
SCHEMBL19171283 0.85 CA1 (0.72) CA1CA2PDE3APDE4BPDE4A
SCHEMBL5583464 0.85 CA1 (0.73) CA1CA2PDE3APDE4BPDE4A
SCHEMBL499993 0.85 CA1 (0.73) CA1CA2PDE3APDE4BPDE4A
SCHEMBL500220 0.83 CA1 (0.71) CA1CA2PDE3APDE4BPDE4A
SCHEMBL5583179 0.83 CA1 (0.71) CA1CA2PDE3APDE4BPDE4A
SCHEMBL2532096 0.82 PDE4B (1.00) CA1CA2PDE3APDE4BPDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 469 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250099495-A1 METHODS OF INHIBITING KLEBSIELLA PNEUMONIAE CARBAPENEMASE-2 CITY UNIVERSITY OF HONG KONG (CN) 2025-03-27 US claimed
EP-4100413-A1 ANTIMICROBIAL COMPOUNDS AND COMPOSITIONS AgroFresh Inc. (US) 2022-12-14 EP claimed
CN-115348965-A Antimicrobial compounds and compositions 阿格洛法士公司 2022-11-15 CN claimed
WO-2021158595-A1 ANTIMICROBIAL COMPOUNDS AND COMPOSITIONS AGROFRESH INC. (US) 2021-08-12 WO claimed
CN-106413720-B Volatile application against pathogens 阿格洛法士公司 2020-09-04 CN claimed
US-20200179340-A1 ANTIFUNGAL AGENTS F2G LTD (GB) 2020-06-11 US claimed
US-10596150-B2 Antifungal agents F2G LIMITED (GB) 2020-03-24 US claimed
US-20190314333-A1 ANTIFUNGAL AGENTS F2G LTD (GB) 2019-10-17 US claimed
US-10435419-B2 Process for the preparation of tavaborole, its novel polymorphic forms and the polymorphs thereof BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) 2019-10-08 US claimed
EP-3261437-B1 FUNGICIDAL COMPOUNDS AND COMPOSITIONS AGROFRESH INC (US) 2019-09-11 EP claimed
US-20140213551-A1 COMPOUNDS AND COMPOSITIONS DOW AGROSCIENCE LLC (US) 2014-07-31 US claimed
US-8669207-B1 Compounds and compositions DOW AGROSCIENCES, LLC. (US) 2014-03-11 US claimed
US-7767657-B2 Boron-containing small molecules ANACOR PHARMACEUTICALS, INC. (US) 2010-08-03 US claimed
US-7582621-B2 Topically treating ungal and periungal infections of the nails, hoofs and claws of mammals by treating with 1-hydroxy-5-fluoro-1,3-dihydro-2,1-benzoxyborole; effectively penetrates the nail; onychomycosis; tinea unguium; fungicides; viricides; bactericides; parasiticides; yeast; microbiocides ANACOR PHARMACEUTICALS, INC. (US) 2009-09-01 US claimed
EP-2066789-A2 CRYSTAL STRUCTURE OF A TRNA SYNTHETASE Anacor Pharmaceuticals, Inc. (US) 2009-06-10 EP claimed
EP-1976536-A2 BORON-CONTAINING SMALL MOLECULES Anacor Pharmaceuticals, Inc. (US) 2008-10-08 EP claimed
WO-2008070257-A9 CRYSTAL STRUCTURE OF A TRNA SYNTHETASE ANACOR PHARMACEUTICALS INC (US) 2008-09-04 WO claimed
WO-2008070257-A2 CRYSTAL STRUCTURE OF A TRNA SYNTHETASE ANACOR PHARMACEUTICALS, INC. (US) 2008-06-12 WO claimed
WO-2007078340-A2 BORON-CONTAINING SMALL MOLECULES ANACOR PHARMACEUTICALS, INC. (US) 2007-07-12 WO claimed
US-20070155699-A1 Boron-containing small molecules ANACOR PHARMACEUTICALS (US) 2007-07-05 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200179340-A1 ANTIFUNGAL AGENTS DPM1, AADAC, PIK3C3 CA1 1523/4885CA2 132/4885PDE3A 528/4885
US-20070155699-A1 Boron-containing small molecules ETF1, POLR1C, DPM1 CA1 4091/4885CA2 1368/4885PDE3A 4505/4885
US-20140213551-A1 COMPOUNDS AND COMPOSITIONS OXA1L, CUL3, CUL2 CA1 3015/4885CA2 2198/4885PDE3A 1840/4885
US-20190314333-A1 ANTIFUNGAL AGENTS DPM1, AADAC, PIK3C3 CA1 1523/4885CA2 132/4885PDE3A 528/4885
US-10435419-B2 Process for the preparation of tavaborole, its novel polymorphic forms and the polymorphs thereof HLA-B, VKORC1L1, VPS4B CA1 4579/4885CA2 4423/4885PDE3A 3861/4885
US-10596150-B2 Antifungal agents DPM1, AADAC, PIK3C3 CA1 1523/4885CA2 132/4885PDE3A 528/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.