Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | MARS1 | P56192 | 3/20 | 0.49 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | GABRE | P78334 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790569 | 0.92 | MAPKAPK2 (0.57) | MAPKAPK2MARS1HDAC1GSK3BMAPT | |
| SCHEMBL29120797 | 0.92 | MARS1 (0.53) | MAPKAPK2MARS1GABRPGABRDGABRA1 | |
| SCHEMBL4716100 | 0.86 | GABRA1 (0.48) | MAPKAPK2MARS1GABRPGABRDGABRA1 | |
| Hydrochloric Acid SCHEMBL4717533 | 0.85 | GABRA1 (0.47) | MAPKAPK2MARS1GABRPGABRDGABRA1 | |
| Trifluoroacetic Acid SCHEMBL4718586 | 0.85 | MAPKAPK2 (0.52) | MAPKAPK2MARS1HDAC1HDAC3HDAC4 | |
| SCHEMBL14188353 | 0.83 | MAPKAPK2 (0.58) | MAPKAPK2MARS1GABRA1GABRB2HDAC1 | |
| SCHEMBL14188422 | 0.83 | SMN1; SMN2 (0.55) | GSK3BMAPTPOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4718376 | 0.82 | MAPKAPK2 (0.57) | MAPKAPK2MARS1GABRA1GABRB2HDAC1 | |
| Hydrochloric Acid SCHEMBL5002465 | 0.82 | SMN1; SMN2 (0.54) | GSK3BMAPTPOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4716157 | 0.81 | GABRA1 (0.51) | MAPKAPK2GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | MAPKAPK2 2/4885MARS1 2800/4885GABRP 2995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.