SCHEMBL5000622

SCHEMBL5000622

COC(=O)c1cc(Oc2ccc(N)cc2)cc(C(=O)OC)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.60
PARP10 Q53GL7 2/20 0.53
ALDH1A1 P00352 5/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
TDP1 Q9NUW8 2/20 0.48
CYP3A4 P08684 1/20 0.48
TSHR P16473 1/20 0.48
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
TEAD4 Q15561 1/20 0.46
MAPT P10636 5/20 0.45
GAA P10253 4/20 0.45
KDM4E B2RXH2 1/20 0.45
GLA P06280 1/20 0.45
HPGD P15428 1/20 0.45
CASP1 P29466 1/20 0.45
CASP7 P55210 1/20 0.45
ATM Q13315 1/20 0.45
HSD17B10 Q99714 1/20 0.45
MAPK1 P28482 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10078186 0.97 USP2 (0.56) USP2PARP10ALDH1A1SMN1; SMN2TDP1
SCHEMBL4242980 0.87 PARP10 (0.63) PARP10ALDH1A1SMN1; SMN2TDP1CYP3A4
SCHEMBL9072522 0.87 USP2 (0.48) USP2PARP10ALDH1A1SMN1; SMN2MAPT
SCHEMBL5873911 0.85 SMN1; SMN2 (0.58) USP2PARP10ALDH1A1SMN1; SMN2MAPT
SCHEMBL6350638 0.84 CA1 (0.60) USP2PARP10ALDH1A1TDP1CA1
SCHEMBL2891300 0.83 ATM (0.51) USP2PARP10ALDH1A1ATM
SCHEMBL15055140 0.83 USP2 (0.50) USP2ALDH1A1CA1CA2MAPT
SCHEMBL5000641 0.83 USP2 (0.53) USP2ALDH1A1SMN1; SMN2TDP1TSHR
SCHEMBL10895053 0.83 USP2 (0.53) USP2ALDH1A1SMN1; SMN2TDP1TSHR
SCHEMBL184785 0.83 KDM4E (0.58) USP2ALDH1A1TDP1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8337982-B2 Comprising first repeating unit obtained by reaction of bisaminophenol compound and dicarboxylic acid, at least one of which has diamondoid structure and second repeating unit obtained by reaction of bisaminophenol compound having no diamondoid structure and dicarboxylic acid; heat resistance SUMITOMO BAKELITE CO., LTD. (JP) 2012-12-25 US disclosed
US-20080206548-A1 Benzoxazole Resin Precursor, Polybenzoxazole Resin, Resin Film And Semiconductor Device SUMITOMO BAKELITE CO., LTD (JP) 2008-08-28 US disclosed
EP-1832619-A1 BENZOXAZOLE RESIN PRECURSOR, POLYBENZOXAZOLE RESIN, RESIN FILM, AND SEMICONDUCTOR DEVICE Sumitomo Bakelite Company, Limited (JP) 2007-09-12 EP disclosed
US-6949674-B2 Aromatic carboxylic acids, acid halides thereof and processes for preparing both SUMITOMO BAKELITE COMPANY, LTD. (JP) 2005-09-27 US disclosed
US-20040195552-A1 useful as powders or pellets for incorporation into a variety of thermoplastic resins; diacidic anthraquinone compounds WEAVER MAX ALLEN (US) 2004-10-07 US disclosed
US-6776930-B2 POLYMER BONDED TO DYE EASTMAN KODAK COMPANY 2004-08-17 US disclosed
US-20040068139-A1 Aromatic carboxylic acids, acid halides thereof and processes for preparing both SUMITOMO BAKELITE COMPANY, LTD. (JP) 2004-04-08 US disclosed
EP-1346975-A1 AROMATIC CARBOXYLIC ACIDS, ACID HALIDES THEREOF AND PROCESSES FOR PREPARING BOTH SUMITOMO BAKELITE CO., LTD. (JP) 2003-09-24 EP disclosed
US-20010023938-A1 Polymer bonded to dye ALLEN MAX (US) 2001-09-27 US disclosed
US-6197223-B1 REACTING DIACIDIC MONOMER HAVING FORMULA H--A--H, COMPRISING 1 TO 100 MOLE % OF LIGHT-ABSORBING MONOMER HAVING A LIGHT ABSORPTION MAXIMUM BETWEEN 300 NM AND 1200 NM AND 99-0 MOLE % OF A NON-LIGHT ABSORBING MONOMER WITH ORGANIC COMPOUND EASTMAN CHEMICAL COMPANY 2001-03-06 US disclosed
EP-0948570-A1 METHOD FOR PREPARING LIGHT-ABSORBING POLYMERIC COMPOSITIONS EASTMAN CHEMICAL COMPANY (US) 1999-10-13 EP disclosed
WO-1998023690-A9 METHOD FOR PREPARING LIGHT-ABSORBING POLYMERIC COMPOSITIONS 1998-09-17 WO disclosed
WO-1998023690-A1 METHOD FOR PREPARING LIGHT-ABSORBING POLYMERIC COMPOSITIONS EASTMAN CHEMICAL COMPANY (US) 1998-06-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040068139-A1 Aromatic carboxylic acids, acid halides thereof and processes for preparing both CCR1, CCRL2, CCR6 USP2 579/4885PARP10 2322/4885ALDH1A1 54/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.