Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 6/20 | 0.63 |
| ▸ | PRKCG | P05129 | 6/20 | 0.63 |
| ▸ | PRKCB | P05771 | 6/20 | 0.63 |
| ▸ | PRKCA | P17252 | 6/20 | 0.63 |
| ▸ | PRKCH | P24723 | 6/20 | 0.63 |
| ▸ | PRKCI | P41743 | 6/20 | 0.63 |
| ▸ | PRKCE | Q02156 | 6/20 | 0.63 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.63 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.63 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.63 |
| ▸ | PRKD1 | Q15139 | 6/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | PRKACA | P17612 | 4/20 | 0.60 |
| ▸ | PRKACG | P22612 | 4/20 | 0.60 |
| ▸ | PRKACB | P22694 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10978592 | 0.84 | PRKCG (0.70) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL7481978 | 0.81 | PRKCG (0.68) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL9541267 | 0.81 | PRKD3 (0.61) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL10983368 | 0.81 | PRKCG (0.73) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL3577992 | 0.80 | NSD2 (0.65) | CYP3A4LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9541290 | 0.80 | PRKCG (0.86) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL8771380 | 0.80 | CYP3A4 (0.56) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL10981545 | 0.79 | PRKCG (0.74) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL13677595 | 0.79 | CYP3A4 (0.58) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL10554867 | 0.79 | PRKD3 (0.53) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414063-B2 | Inhibitors of Akt (protein kinase B) | ELI LILLY AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | ELI LILLY AND COMPANY | 2007-02-22 | — | — | US | disclosed |
| CN-1768040-A | Isoquinoline-5-sulfonic acid amides as inhibitors of AKT (protein kinase B) | LILLY CO ELI (US) | 2006-05-03 | — | — | CN | disclosed |
| EP-1611105-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004094386-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | AKT1, AKT2, BRAF | PRKD3 353/4885PRKCG 288/4885PRKCB 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.