Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 4/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.45 |
| ▸ | YES1 | P07947 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | HIPK1 | Q86Z02 | 3/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4997671 | 0.88 | KDM4E (0.45) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4997409 | 0.88 | L3MBTL1 (0.52) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5000619 | 0.87 | MAPT (0.60) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4997547 | 0.87 | MAPT (0.48) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4996238 | 0.85 | NPC1 (0.50) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5000847 | 0.85 | CHEK1 (0.46) | NPC1MAPTRAB9ASMN1; SMN2CHEK1 | |
| SCHEMBL4997726 | 0.85 | HRH1 (0.51) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4994760 | 0.84 | CHEK1 (0.65) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4997110 | 0.84 | MAP4K1 (0.48) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4995533 | 0.83 | NPC1 (0.47) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | ALDH1A1 1034/4885NPC1 2008/4885MAPT 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.