Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | YES1 | P07947 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996925 | 0.89 | MAPT (0.53) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4992338 | 0.88 | NPC1 (0.61) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4997409 | 0.88 | L3MBTL1 (0.52) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5000709 | 0.87 | ALDH1A1 (0.50) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4991471 | 0.86 | CYP1A2 (0.57) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4993281 | 0.86 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4996226 | 0.85 | CHEK1 (0.48) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4997547 | 0.84 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4994760 | 0.84 | CHEK1 (0.65) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4995514 | 0.83 | HPGD (0.46) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | MAPT 5/4885ALDH1A1 1034/4885SMN1; SMN2 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.