⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000825 | 1.00 | — | — | |
| SCHEMBL5004579 | 0.73 | ALOX5 (0.36) | — | |
| SCHEMBL14779251 | 0.64 | USP2 (0.37) | — | |
| SCHEMBL13839339 | 0.62 | — | — | |
| SCHEMBL22735285 | 0.61 | USP2 (0.36) | — | |
| SCHEMBL22664613 | 0.61 | USP2 (0.32) | — | |
| SCHEMBL22692824 | 0.61 | USP2 (0.32) | — | |
| SCHEMBL14779748 | 0.60 | ACHE (0.37) | — | |
| SCHEMBL14440049 | 0.60 | USP2 (0.33) | — | |
| SCHEMBL14671354 | 0.60 | ACHE (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161306-A1 | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | US | disclosed |
| EP-1856044-A2 | PYRROLE DERIVATIVES AS DNA GYRASE AND TOPOISOMERASE INHIBITORS | AstraZeneca AB (SE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006087548-A2 | PYRROLE DERIVATIVES AS DNA GYRASE AND TOPOISOMERASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-08-24 | — | — | WO | disclosed |