Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 11/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5001845 | 1.00 | BDKRB1 (0.41) | BDKRB1PIK3CGAIMP2MEN1KMT2A | |
| SCHEMBL5001647 | 0.94 | BDKRB1 (0.43) | BDKRB1AIMP2MEN1KMT2A | |
| SCHEMBL5001688 | 0.94 | BDKRB1 (0.43) | BDKRB1AIMP2MEN1KMT2A | |
| SCHEMBL5002159 | 0.93 | BDKRB1 (0.41) | BDKRB1AIMP2MEN1KMT2ALMNA | |
| SCHEMBL14138919 | 0.87 | PRMT5 (0.35) | BDKRB1MEN1KMT2AALDH1A1MCHR1 | |
| SCHEMBL5106378 | 0.84 | BDKRB1 (0.36) | BDKRB1MEN1KMT2AMCHR1 | |
| SCHEMBL5145168 | 0.84 | BDKRB1 (0.36) | BDKRB1MEN1KMT2AMCHR1 | |
| SCHEMBL5001659 | 0.83 | BDKRB1 (0.44) | BDKRB1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5001661 | 0.83 | BDKRB1 (0.44) | BDKRB1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14029683 | 0.83 | BDKRB1 (0.44) | BDKRB1LMNAALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249106-A1 | 3-(1-((R)-7-((4-fluoropiperidin-1-yl)methyl)-3,4-dihydro-2H-chromen-4-yl)-1H-1,2,3-triazol-4-yl)-2-(4-methylphenylsulfonamido)propanoic acid; chronic pain analgesics; side effect reduction | AMGEN INC. | 2008-10-09 | — | — | US | disclosed |
| US-7414134-B2 | B1 bradykinin receptor antagonists | AMGEN INC. (US) | 2008-08-19 | — | — | US | disclosed |
| US-20060100216-A1 | Novel B1 bradykinin receptor antagonists | AMGEN INC. (US) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249106-A1 | 3-(1-((R)-7-((4-fluoropiperidin-1-yl)methyl)-3,4-dihydro-2H-chromen-4-yl)-1H-1,2,3-triazol-4-yl)-2-(4-methylphenylsulfonamido)propanoic acid; chronic pain analgesics; side effect reduction | BDKRB1, BDKRB2, FPR1 | BDKRB1 1/4885PIK3CG 2864/4885AIMP2 4256/4885 |
| US-20060100216-A1 | Novel B1 bradykinin receptor antagonists | BDKRB1, BDKRB2, EDNRB | BDKRB1 1/4885PIK3CG 3522/4885AIMP2 3546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.