Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28704783 | 0.78 | TYMS (0.44) | TYMSKMT2AMEN1CYP3A4TDP1 | |
| SCHEMBL28690604 | 0.78 | TYMS (0.50) | TYMSKMT2AMEN1CYP3A4TDP1 | |
| SCHEMBL728920 | 0.73 | ERN1 (0.45) | ALDH1A1HSD17B10MAPTKDM4ECDK4 | |
| SCHEMBL16178927 | 0.71 | CYP1A2 (0.56) | KMT2ACYP3A4TDP1ALDH1A1TSHR | |
| SCHEMBL4971065 | 0.70 | CDK4 (0.40) | CYP3A4PTPN22TDP1ALDH1A1CYP2A6 | |
| Hydrochloric Acid SCHEMBL30262984 | 0.70 | CYP1A2 (0.54) | KMT2ACYP3A4ALDH1A1TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL4998206 | 0.69 | PTPN22 (0.42) | KMT2AMEN1CYP3A4PTPN22TDP1 | |
| SCHEMBL15797613 | 0.69 | SMN1; SMN2 (0.43) | TYMSKMT2AMEN1CYP3A4TDP1 | |
| SCHEMBL15545385 | 0.69 | HSD17B10 (0.52) | TYMSKMT2AMEN1CYP3A4PTPN22 | |
| SCHEMBL8886826 | 0.68 | CDK4 (0.50) | TYMSKMT2AMEN1CYP3A4ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234327-A1 | DIHYDROINDAZOLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234327-A1 | DIHYDROINDAZOLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | FECH, SLC40A1, HAMP | TYMS 1091/4885KMT2A 1932/4885MEN1 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.