Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13631717 | 0.88 | TSHR (0.40) | TSHRPDE5APDE4APDE4BPDE4C | |
| SCHEMBL13631390 | 0.86 | TSHR (0.39) | TSHRPDE5A | |
| SCHEMBL1418450 | 0.86 | TSHR (0.41) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7505873 | 0.86 | TSHR (0.41) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13992733 | 0.80 | AOX1 (0.43) | TSHR | |
| SCHEMBL13992767 | 0.78 | CXCR4 (0.46) | TSHR | |
| SCHEMBL22014309 | 0.78 | TSHR (0.50) | TSHR | |
| SCHEMBL5002884 | 0.74 | KDM4E (0.33) | — | |
| SCHEMBL14113843 | 0.72 | TSHR (0.40) | TSHR | |
| SCHEMBL13631583 | 0.71 | TSHR (0.43) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312430-A1 | Method of Preparing or Synthesizing Polyazamacrocycle Derivatives | THERAPHARM GMBH (CH) | 2008-12-18 | — | — | US | disclosed |
| EP-1812453-A1 | METHOD OF PREPARING OR SYNTHESIZING POLYAZAMACROCYCLE DERIVATIVES | Therapharm GmbH (CH) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006045546-A1 | METHOD OF PREPARING OR SYNTHESIZING POLYAZAMACROCYCLE DERIVATIVES | THERAPHARM GMBH (CH) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312430-A1 | Method of Preparing or Synthesizing Polyazamacrocycle Derivatives | POLI, PARP1, DHPS | TSHR 4034/4885PDE5A 2526/4885PDE4A 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.