Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009495 | 0.98 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2HRH1HTR2AHTR2C | |
| SCHEMBL21047551 | 0.93 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2HRH1HTR2AHTR2C | |
| SCHEMBL21047253 | 0.77 | BCHE (0.44) | ALDH1A1SMN1; SMN2HRH1HTR2AHTR2C | |
| SCHEMBL10859973 | 0.77 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2HRH1HTR2AHTR2C | |
| SCHEMBL21047419 | 0.76 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HRH1HTR2AHTR2C | |
| SCHEMBL21047409 | 0.75 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2HRH1HTR2AHTR2C | |
| SCHEMBL21047431 | 0.74 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2HRH1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL3371779 | 0.74 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM2B | |
| SCHEMBL27097525 | 0.72 | OPRL1 (0.33) | HRH3 | |
| SCHEMBL22160003 | 0.72 | CYP2C19 (0.67) | ALDH1A1SMN1; SMN2GRM5KDM4ECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280879-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280879-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | XDH, CYP2D6, F12 | ALDH1A1 3777/4885SMN1; SMN2 4085/4885HRH1 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.