Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146777 | 0.80 | — | — | |
| SCHEMBL23877661 | 0.76 | — | — | |
| Propylene Glycol SCHEMBL975266 | 0.76 | — | — | |
| Propylene Glycol SCHEMBL7572232 | 0.76 | TDP1 (0.77) | TDP1TSHRLMNAALDH1A1 | |
| Propylene Glycol SCHEMBL10432465 | 0.76 | — | — | |
| Propylene Glycol SCHEMBL574958 | 0.74 | — | — | |
| Propylene Glycol SCHEMBL600550 | 0.73 | — | — | |
| Propylene Glycol SCHEMBL28349323 | 0.73 | TDP1 (0.83) | TDP1TSHRHSD17B10LMNAALDH1A1 | |
| Propylene Glycol SCHEMBL988548 | 0.73 | TDP1 (0.83) | TDP1TSHRHSD17B10LMNAALDH1A1 | |
| Propylene Glycol SCHEMBL27397419 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765277-B1 | MASCARA COMPOSITION | AVON PROD INC (US) | 2015-04-08 | — | — | EP | claimed |
| US-8128918-B2 | Mascara composition | AVON PRODUCTS, INC. (US) | 2012-03-06 | — | — | US | claimed |
| US-20110085998-A1 | Mascara Composition | AVON PRODUCTS, INC. (US) | 2011-04-14 | — | — | US | claimed |
| US-20090087397-A1 | Mascara Composition | AVON PRODUCTS, INC. (US) | 2009-04-02 | — | — | US | claimed |
| US-7431919-B2 | Base composition with a hair conditioner for improved moisture and impact strength; low viscosity with low concentrations of surfactant and wax are easily removed; excellent buildup, lengthening and wear | AVON PRODUCTS, INC (US) | 2008-10-07 | — | — | US | claimed |
| EP-1765277-A1 | MASCARA COMPOSITION | AVON PRODUCTS, INC. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2005018599-A1 | MASCARA COMPOSITION | AVON PRODUCTS, INC. (US) | 2005-03-03 | — | — | WO | claimed |
| US-20050042191-A1 | Mascara composition | CITIBANK, N.A., LONDON BRANCH | 2005-02-24 | — | — | US | claimed |
| US-9192550-B2 | Magnetically-oriented cosmetic fibers | AVON PRODUCTS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| EP-1765277-B1 | MASCARA COMPOSITION | AVON PROD INC (US) | 2015-04-08 | — | — | EP | disclosed |
| EP-2585026-A1 | MAGNETICALLY-ORIENTED COSMETIC FIBERS | Avon Products, Inc. (US) | 2013-05-01 | — | — | EP | disclosed |
| US-8128918-B2 | Mascara composition | AVON PRODUCTS, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| WO-2011162967-A1 | MAGNETICALLY-ORIENTED COSMETIC FIBERS | AVON PRODUCTS, INC. (US) | 2011-12-29 | — | — | WO | disclosed |
| US-20110085998-A1 | Mascara Composition | AVON PRODUCTS, INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20090087397-A1 | Mascara Composition | AVON PRODUCTS, INC. (US) | 2009-04-02 | — | — | US | disclosed |
| US-7431919-B2 | Base composition with a hair conditioner for improved moisture and impact strength; low viscosity with low concentrations of surfactant and wax are easily removed; excellent buildup, lengthening and wear | AVON PRODUCTS, INC (US) | 2008-10-07 | — | — | US | disclosed |
| EP-1765277-A1 | MASCARA COMPOSITION | AVON PRODUCTS, INC. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005018599-A1 | MASCARA COMPOSITION | AVON PRODUCTS, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20050042191-A1 | Mascara composition | CITIBANK, N.A., LONDON BRANCH | 2005-02-24 | — | — | US | disclosed |