Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | FAAH | O00519 | 5/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.48 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28417853 | 1.00 | GPR84 (0.50) | GPR84FAAHFFAR1ACE2CNR1 | |
| SCHEMBL13713631 | 0.91 | FAAH (0.47) | GPR84FAAHFFAR1ACE2CNR1 | |
| SCHEMBL11798879 | 0.91 | FAAH (0.47) | GPR84FAAHFFAR1ACE2CNR1 | |
| SCHEMBL17240353 | 0.91 | FAAH (0.47) | GPR84FAAHFFAR1ACE2CNR1 | |
| SCHEMBL28549144 | 0.89 | — | — | |
| SCHEMBL13407751 | 0.82 | — | — | |
| SCHEMBL654708 | 0.79 | FAAH (0.59) | GPR84FAAHFFAR1ACE2CNR1 | |
| SCHEMBL1839719 | 0.79 | FAAH (0.59) | GPR84FAAHFFAR1ACE2CNR1 | |
| SCHEMBL1836768 | 0.79 | FAAH (0.59) | GPR84FAAHFFAR1ACE2CNR1 | |
| SCHEMBL1833744 | 0.79 | FAAH (0.59) | GPR84FAAHFFAR1ACE2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446074-B2 | aqueous emulsions comprising a protective colloid partly saponified polyvinyl acetate, a non-ionic emulsifier, and an anti-freeze agent; small peroxide droplet sizes | AKZO NOBEL N.V. (NL) | 2008-11-04 | — | — | US | disclosed |
| US-20050171275-A1 | aqueous emulsions comprising a protective colloid partly saponified polyvinyl acetate, a non-ionic emulsifier, and an anti-freeze agent; small peroxide droplet sizes | AKZO NOBEL N.V. (NL) | 2005-08-04 | — | — | US | disclosed |