Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009259 | 0.88 | POLB (0.42) | MAPK1POLBGSK3BHDAC3HDAC1 | |
| SCHEMBL2395007 | 0.87 | MAPT (0.48) | MAPK1POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL5005989 | 0.82 | SMN1; SMN2 (0.42) | MAPK1POLBGSK3BHDAC3HDAC1 | |
| SCHEMBL5006811 | 0.77 | GSK3B (0.43) | MAPK1POLBGSK3BHDAC3HDAC1 | |
| SCHEMBL5006829 | 0.75 | NPC1 (0.42) | MAPK1POLBALDH1A1MEN1MAPT | |
| SCHEMBL16690227 | 0.75 | GSK3B (0.61) | MAPK1POLBGSK3BTDP1ALDH1A1 | |
| Water SCHEMBL29199054 | 0.73 | GSK3B (0.59) | MAPK1POLBGSK3BTDP1ALDH1A1 | |
| SCHEMBL14041426 | 0.72 | GSK3B (0.61) | MAPK1GSK3BTDP1ALDH1A1HSD11B1 | |
| Ammonia Solution, Strong SCHEMBL17187555 | 0.70 | MAPK1 (0.55) | MAPK1POLBGSK3BHDAC3HDAC1 | |
| SCHEMBL2308129 | 0.70 | MAPT (0.37) | MAPK1POLBALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |