Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5005989 | 0.87 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2L3MBTL1LMNACYP1A2 | |
| SCHEMBL2395037 | 0.83 | GSK3B (0.39) | MAPTSMN1; SMN2L3MBTL1LMNACYP1A2 | |
| SCHEMBL5007313 | 0.81 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2L3MBTL1MAOAALDH1A1 | |
| SCHEMBL1748034 | 0.73 | SMN1; SMN2 (0.44) | MAPTSMN1; SMN2L3MBTL1LMNACYP1A2 | |
| SCHEMBL13355120 | 0.71 | ARG1 (0.36) | CYP1A2ALDH1A1 | |
| SCHEMBL5006820 | 0.70 | MAPK1 (0.46) | MAPTALDH1A1MAPK1KDM4EGAA | |
| SCHEMBL595610 | 0.70 | GAA (0.43) | MAPTSMN1; SMN2L3MBTL1LMNACYP1A2 | |
| SCHEMBL5006828 | 0.69 | RARB (0.41) | SMN1; SMN2PDE4DNPC1RAB9AHIF1A | |
| SCHEMBL5006811 | 0.69 | GSK3B (0.43) | MAPTSMN1; SMN2L3MBTL1LMNACYP3A4 | |
| SCHEMBL20159133 | 0.68 | LMNA (0.43) | MAPTLMNACYP1A2CYP3A4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | disclosed |
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |