SCHEMBL5007159

SCHEMBL5007159

C=CCOC(=O)c1sc(OCCC)c(Br)c1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.39
CYP2D6 P10635 2/20 0.39
KCNH2 Q12809 1/20 0.39
MAPT P10636 4/20 0.39
KDM4E B2RXH2 4/20 0.37
NPC1 O15118 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
HSP90AA1 P07900 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
ALDH1A1 P00352 5/20 0.34
KMT2A Q03164 4/20 0.34
RAB9A P51151 3/20 0.34
GAA P10253 3/20 0.34
TSHR P16473 2/20 0.34
HSD17B10 Q99714 1/20 0.34
LMNA P02545 2/20 0.34
TP53 P04637 1/20 0.34
HPGD P15428 1/20 0.34
POLB P06746 1/20 0.33
MEN1 O00255 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5228048 0.81 ALDH1A1 (0.44) CYP3A4CYP2D6KCNH2MAPTKDM4E
SCHEMBL5000071 0.74 ALOX15 (0.41) CYP3A4MAPTKDM4ENPC1SMN1; SMN2
SCHEMBL4973028 0.72 CYP3A4 (0.42) CYP3A4CYP2D6KCNH2MAPTLMNA
Succinimide SCHEMBL4972452 0.68 CYP3A4 (0.41) CYP3A4CYP2D6KCNH2MAPTGAA
SCHEMBL10779321 0.65 CYP3A4 (0.53) CYP3A4MAPTKDM4ESMN1; SMN2ALDH1A1
SCHEMBL5271074 0.65 MAPT (0.53) KCNH2MAPTKDM4ENPC1SMN1; SMN2
SCHEMBL289840 0.63 CYP3A4 (0.52) CYP3A4MAPTKDM4ESMN1; SMN2ALDH1A1
SCHEMBL4787535 0.63 CYP3A4 (0.47) CYP3A4MAPTKDM4ENPC1SMN1; SMN2
SCHEMBL21612062 0.62 MAPT (0.68) MAPTKDM4ENPC1SMN1; SMN2ALDH1A1
SCHEMBL10531626 0.62 CYP3A4 (0.50) CYP3A4MAPTKDM4ESMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008115912-A1 REGIO-SPECIFIC SYNTHESIS OF 4-BROMO-3-METHYL-5-PROPOXY-THIOPHENE-2-CARBOXYLIC ACID SANOFI-AVENTIS (FR) 2008-09-25 WO claimed
WO-2008121666-A1 USE OF 4-BROMO-3-METHYL-5-PROPOXYTHIOPHENE-2-CARBOXYLIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER FOR PREPARING THE TRYPTASE INHIBITOR [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(4-BROMO-3-METHYL-5-PROPOXY-THIOPHEN-2-YL)-METHANONE SANOFI-AVENTIS (FR) 2008-10-09 WO disclosed
WO-2008115912-A1 REGIO-SPECIFIC SYNTHESIS OF 4-BROMO-3-METHYL-5-PROPOXY-THIOPHENE-2-CARBOXYLIC ACID SANOFI-AVENTIS (FR) 2008-09-25 WO disclosed
WO-2008115912-A1 REGIO-SPECIFIC SYNTHESIS OF 4-BROMO-3-METHYL-5-PROPOXY-THIOPHENE-2-CARBOXYLIC ACID SANOFI-AVENTIS (FR) 2008-09-25 WO disclosed