Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5001155 | 0.82 | PTGS2 (0.37) | PTGS2PTGS1BRD4 | |
| SCHEMBL5007425 | 0.80 | GALR1 (0.36) | PTGS2PTGS1KMT2ABRD4 | |
| SCHEMBL4994770 | 0.78 | PTGS2 (0.34) | PTGS2PTGS1BRD4 | |
| SCHEMBL5963380 | 0.72 | GALR1 (0.40) | KMT2ASMN1; SMN2 | |
| SCHEMBL5963597 | 0.69 | GALR1 (0.38) | SMN1; SMN2 | |
| SCHEMBL5964141 | 0.69 | GRIA2 (0.36) | — | |
| SCHEMBL8384211 | 0.64 | PTGS2 (0.88) | PTGS2PTGS1 | |
| SCHEMBL12341698 | 0.62 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL5963305 | 0.62 | SLC6A3 (0.39) | — | |
| SCHEMBL6994135 | 0.62 | PTGS2 (0.43) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396846-B2 | Growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| US-7396846-B2 | Growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| US-7396846-B2 | Growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| US-20050240001-A1 | 2-(2-Amino-2-methylpropionylamino)-3-(2,6-difluoro-3-methylphenyl)methoxy propionic acid N-[5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-ylmethyl]-N-ethylamide; endogenous human growth hormone controller; non-peptidyl in nature, more metabolically stable | ELI LILLY AND COMPANY (US) | 2005-10-27 | — | — | US | disclosed |