Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 2/20 | 0.86 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.69 |
| ▸ | OSBP | P22059 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.65 |
| ▸ | RORC | P51449 | 1/20 | 0.65 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.65 |
| ▸ | GBA1 | P04062 | 2/20 | 0.63 |
| ▸ | UGCG | Q16739 | 2/20 | 0.63 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.63 |
| ▸ | NPC1L1 | Q9UHC9 | 5/20 | 0.63 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474688 | 1.00 | POLA1 (0.86) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL16790328 | 1.00 | POLA1 (0.86) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL22662412 | 1.00 | POLA1 (0.86) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL17149949 | 0.99 | POLA1 (0.85) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL17775751 | 0.99 | POLA1 (0.85) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL16306859 | 0.93 | POLA1 (1.00) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL587901 | 0.93 | POLA1 (1.00) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL1708156 | 0.93 | POLA1 (1.00) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL13147079 | 0.93 | POLA1 (1.00) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL587902 | 0.93 | POLA1 (1.00) | POLA1CYP46A1OSBPUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7455856-B2 | Lipid-derivatized bisphosphonic acid | MCS MICRO CARRIER SYSTEMS GMBH (DE) | 2008-11-25 | — | — | US | disclosed |
| US-20070154537-A1 | Lipid-derivatized bisphosphonic acid | MCS MICRO CARRIER SYSTEMS GMBH (DE) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070154537-A1 | Lipid-derivatized bisphosphonic acid | SGMS1, PHOSPHO1, SGMS2 | POLA1 3262/4885CYP46A1 309/4885OSBP 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.