⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1038844 | 0.73 | — | — | |
| SCHEMBL442812 | 0.73 | — | — | |
| SCHEMBL438270 | 0.73 | POLB (0.33) | — | |
| SCHEMBL1898922 | 0.71 | — | — | |
| SCHEMBL10515359 | 0.69 | ABCG2 (0.36) | — | |
| SCHEMBL452883 | 0.68 | — | — | |
| SCHEMBL4413227 | 0.68 | POLB (0.31) | — | |
| SCHEMBL5326093 | 0.68 | MAOA (0.37) | — | |
| SCHEMBL11227302 | 0.64 | MAOA (0.33) | — | |
| SCHEMBL3072276 | 0.64 | MAOA (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492431-B2 | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity | JANSSEN PHARMACEUTICA, N.V. (BE) | 2013-07-23 | — | — | US | claimed |
| EP-1968573-A2 | USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MANIA AND BIPOLAR DISORDER | Janssen Pharmaceutica, N.V. (BE) | 2008-09-17 | — | — | EP | claimed |
| WO-2007075695-A2 | USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MANIA AND BIPOLAR DISORDER | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-05 | — | — | WO | claimed |