Sugi Predict

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SCHEMBL5010641

SCHEMBL5010641

CN(C(=O)c1cc(NC(=O)c2cc(F)c(F)cc2Cl)[nH]n1)c1ccc(-c2nc(=O)o[nH]2)cc1

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PYGL P06737 2/20 0.37
▸ CYP2C19 P33261 1/20 0.36
▸ NPC1 O15118 4/20 0.35
▸ RAB9A P51151 4/20 0.35
▸ KMT2A Q03164 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ MAPT P10636 1/20 0.33
▸ PRSS12 P56730 1/20 0.33
▸ LMNA P02545 2/20 0.33
▸ GAA P10253 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ HTT P42858 2/20 0.32
▸ RECQL P46063 1/20 0.32
▸ POLB P06746 1/20 0.32
▸ APEX1 P27695 1/20 0.32
▸ CHEK2 O96017 1/20 0.31
▸ NTRK1 P04629 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5013485 0.83 CYP2C19 (0.36) PYGLCYP2C19NPC1RAB9AKMT2A
SCHEMBL14587800 0.83 CYP2C19 (0.37) PYGLCYP2C19NPC1RAB9AKMT2A
SCHEMBL5009741 0.82 CYP2C19 (0.36) PYGLCYP2C19NPC1RAB9AKMT2A
Hydrochloric Acid SCHEMBL5008273 0.82 CYP2C19 (0.37) PYGLCYP2C19NPC1RAB9AKMT2A
SCHEMBL5009797 0.82 NPC1 (0.44) CYP2C19NPC1RAB9AKMT2AMEN1
SCHEMBL14297710 0.81 CYP2C19 (0.41) PYGLCYP2C19NPC1RAB9AKMT2A
SCHEMBL5010646 0.80 CYP2C19 (0.41) PYGLCYP2C19NPC1RAB9AKMT2A
SCHEMBL14301501 0.79 NPC1 (0.41) PYGLCYP2C19NPC1RAB9AKMT2A
SCHEMBL14587798 0.79 CYP2C19 (0.40) PYGLCYP2C19NPC1RAB9AKMT2A
SCHEMBL5010648 0.79 CYP2C19 (0.42) PYGLCYP2C19NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1884513-A1 PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME Japan Tobacco, Inc. (JP) 2008-02-06 — — EP claimed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 — — US claimed
EP-1884513-A1 PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME Japan Tobacco, Inc. (JP) 2008-02-06 — — EP disclosed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 — — US disclosed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 — — US disclosed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents PYGL, GYS2, AGL PYGL 1/4885CYP2C19 517/4885NPC1 2838/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.