Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.34 |
| ▸ | PYGL | P06737 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009826 | 0.94 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2HTTRECQL | |
| SCHEMBL5012119 | 0.91 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2HTTRECQL | |
| SCHEMBL5010796 | 0.91 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2HTTRECQL | |
| SCHEMBL5008403 | 0.91 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2HTTRECQL | |
| SCHEMBL14587651 | 0.90 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2HTTRECQL | |
| SCHEMBL5009754 | 0.90 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2HTTRECQL | |
| SCHEMBL5010544 | 0.89 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2HTTRECQL | |
| SCHEMBL5009908 | 0.88 | PYGL (0.41) | NPC1RAB9ASMN1; SMN2HTTRECQL | |
| SCHEMBL5012133 | 0.88 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2HTTRECQL | |
| SCHEMBL5013507 | 0.87 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2SLC6A9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | claimed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | claimed |
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | disclosed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | PYGL, GYS2, AGL | NPC1 2838/4885RAB9A 2748/4885SMN1; SMN2 4705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.