Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015734 | 0.91 | KMT2A (0.44) | KMT2AMEN1 | |
| SCHEMBL5015792 | 0.90 | POLB (0.40) | KMT2ARAB9AMEN1 | |
| SCHEMBL5012239 | 0.90 | KMT2A (0.37) | KMT2AMEN1 | |
| SCHEMBL5015803 | 0.88 | KMT2A (0.34) | KMT2AMEN1 | |
| SCHEMBL5121433 | 0.87 | ALDH1A1 (0.40) | KMT2ACNR1NPC1RAB9AMMP13 | |
| SCHEMBL5054417 | 0.85 | NPC1 (0.39) | KMT2ACNR1NPC1RAB9AMEN1 | |
| SCHEMBL5012874 | 0.85 | NPC1 (0.39) | KMT2ACNR1NPC1RAB9AMEN1 | |
| SCHEMBL5011473 | 0.84 | NPC1 (0.39) | KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL5011231 | 0.79 | KMT2A (0.43) | KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL5015753 | 0.78 | RAB9A (0.41) | KMT2ACNR1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |