⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615269 | 1.00 | ALOX15 (0.50) | — | |
| SCHEMBL3200905 | 0.84 | — | — | |
| SCHEMBL6141 | 0.84 | — | — | |
| SCHEMBL2316627 | 0.83 | — | — | |
| SCHEMBL4401337 | 0.83 | GAA (0.41) | — | |
| SCHEMBL8735020 | 0.83 | ALOX15 (0.81) | — | |
| Hydrochloric Acid SCHEMBL8303248 | 0.81 | — | — | |
| SCHEMBL19286358 | 0.81 | — | — | |
| SCHEMBL20040342 | 0.81 | HRH3 (0.45) | — | |
| SCHEMBL580308 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318204-B2 | pH sensitive block copolymer and polymeric micelle using the same | SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION (KR) | 2012-11-27 | — | — | US | claimed |
| WO-2008130180-A1 | PREPARATION OF DRUG DELIVERY SYSTEMS USING PH-SENSITIVE BLOCK COPOLYMER AND THEIR APPLICATION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-10-30 | — | — | WO | claimed |
| US-20070218120-A1 | Ph Sensitive Block Copolymer and Polymeric Micelle Using the Same | SUNGKYUNKWAN UNIVERSITY FOUNDATIN FOR CORPORATE COLLOBORATION (KR) | 2007-09-20 | — | — | US | claimed |
| WO-2006098547-A1 | PH SENSITIVE BLOCK COPOLYMER AND POLYMERIC MICELLE USING THE SAME | SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION (KR) | 2006-09-21 | — | — | WO | claimed |
| EP-3141582-B1 | SYNTHESIS AND USE OF POLYALKYLAMINES | KARLSRUHER INST TECHNOLOGIE (DE) | 2018-06-13 | — | — | EP | disclosed |
| EP-2811997-B1 | SUBSTITUTED PROLINES/PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS INC (US) | 2018-04-11 | — | — | EP | disclosed |
| US-9896452-B2 | Substituted prolines/piperidines as orexin receptor antagonists | EOLAS THERAPEUTICS, INC. (US) | 2018-02-20 | — | — | US | disclosed |
| US-20170101410-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS, INC. | 2017-04-13 | — | — | US | disclosed |
| US-9499517-B2 | Substituted prolines / piperidines as orexin receptor antagonists | EOLAS THERAPEUTICS, INC. (US) | 2016-11-22 | — | — | US | disclosed |
| US-9440982-B2 | Substituted prolines/piperidines as orexin receptor antagonists | EOLAS THERAPEUTICS, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| WO-2015123355-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS, INC. (US) | 2015-08-20 | — | — | WO | disclosed |
| EP-2811997-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | Eolas Therapeutics Inc. (US) | 2014-12-17 | — | — | EP | disclosed |
| CN-104220065-A | Substituted prolines/piperidines as orexin receptor antagonists | EOLAS THERAPEUTICS INC | 2014-12-17 | — | — | CN | disclosed |
| US-20140364433-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-12-11 | — | — | US | disclosed |
| US-20140364432-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-12-11 | — | — | US | disclosed |
| WO-2013119639-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS, INC. (US) | 2013-08-15 | — | — | WO | disclosed |
| US-8318204-B2 | pH sensitive block copolymer and polymeric micelle using the same | SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION (KR) | 2012-11-27 | — | — | US | disclosed |
| WO-2008130180-A1 | PREPARATION OF DRUG DELIVERY SYSTEMS USING PH-SENSITIVE BLOCK COPOLYMER AND THEIR APPLICATION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-10-30 | — | — | WO | disclosed |
| US-20070218120-A1 | Ph Sensitive Block Copolymer and Polymeric Micelle Using the Same | SUNGKYUNKWAN UNIVERSITY FOUNDATIN FOR CORPORATE COLLOBORATION (KR) | 2007-09-20 | — | — | US | disclosed |
| WO-2006098547-A1 | PH SENSITIVE BLOCK COPOLYMER AND POLYMERIC MICELLE USING THE SAME | SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION (KR) | 2006-09-21 | — | — | WO | disclosed |