Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14173018 | 1.00 | HDAC4 (0.41) | HDAC4SMN1; SMN2NPSR1EPHX1TSHR | |
| SCHEMBL5011562 | 1.00 | HDAC4 (0.41) | HDAC4SMN1; SMN2NPSR1EPHX1TSHR | |
| SCHEMBL14173019 | 0.86 | EPHX1 (0.46) | SMN1; SMN2EPHX1POLBALDH1A1MAPK1 | |
| SCHEMBL5010892 | 0.86 | EPHX1 (0.46) | SMN1; SMN2EPHX1POLBALDH1A1MAPK1 | |
| SCHEMBL5010893 | 0.86 | EPHX1 (0.46) | SMN1; SMN2EPHX1POLBALDH1A1MAPK1 | |
| SCHEMBL14181458 | 0.85 | HCAR2 (0.40) | SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL5010789 | 0.85 | HCAR2 (0.40) | SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL5010792 | 0.85 | HCAR2 (0.40) | SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL14173021 | 0.85 | SMN1; SMN2 (0.41) | HDAC4SMN1; SMN2NPSR1TSHRPOLB | |
| SCHEMBL5014316 | 0.85 | SMN1; SMN2 (0.41) | HDAC4SMN1; SMN2NPSR1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388101-B1 | Tetrahydrofuran derivatives having cis substituent, their intermediates, and their preparation method | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-06-17 | — | — | US | disclosed |