Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 2/20 | 0.45 |
| ▸ | KDM4B | O94953 | 2/20 | 0.45 |
| ▸ | KDM5C | P41229 | 2/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.45 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.32 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011865 | 0.80 | KDM4E (0.61) | KDM4EPKMGPR35DAONPC1 | |
| SCHEMBL3711699 | 0.76 | MAPK8 (0.48) | KDM4EPKMKDM4AKDM4BKDM5C | |
| SCHEMBL20027794 | 0.72 | KDM4E (0.50) | KDM4EPKMKDM4AKDM4BKDM5C | |
| SCHEMBL25779061 | 0.71 | CDC7 (0.50) | KDM4EPKMHSD17B10L3MBTL1 | |
| SCHEMBL2832225 | 0.71 | KDM4E (0.54) | KDM4EPKMKDM4AKDM4BKDM5C | |
| SCHEMBL25779065 | 0.70 | KDM4E (0.50) | KDM4EPKMKDM4AKDM4BKDM5B | |
| SCHEMBL269858 | 0.70 | KDM4E (0.53) | KDM4EPKML3MBTL1 | |
| SCHEMBL14711219 | 0.70 | KDM4E (0.46) | KDM4EPKMHDAC1HDAC6 | |
| SCHEMBL4594949 | 0.69 | — | — | |
| SCHEMBL23294529 | 0.68 | KDM4A (0.42) | KDM4EKDM4AKDM4BKDM5CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312255-A1 | PIPERDINE COMPOUNDS AND USES THEREOF-911 | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312255-A1 | PIPERDINE COMPOUNDS AND USES THEREOF-911 | NISCH, PIR, QDPR | KDM4E 3497/4885PKM 979/4885KDM4A 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.