Sugi Predict

Sugi Predict / Compounds / SCHEMBL269858

SCHEMBL269858

SCHEMBL269858

O=C(O)c1scnc1-c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.53
▸ PKM P14618 1/20 0.50
▸ RORB Q92753 4/20 0.48
▸ CDC7 O00311 1/20 0.45
▸ DBF4 Q9UBU7 1/20 0.45
▸ RORC P51449 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ LMNA P02545 2/20 0.42
▸ DHODH Q02127 2/20 0.41
▸ PDE10A Q9Y233 1/20 0.41
▸ NR4A2 P43354 1/20 0.40
▸ NAPRT Q6XQN6 1/20 0.39
▸ P4HTM Q9NXG6 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ NTRK1 P04629 1/20 0.39
▸ GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27653976 0.89 RORB (0.55) KDM4EPKMRORBCDC7DBF4
SCHEMBL27920106 0.86 KDM4E (0.47) KDM4EPKMRORBCDC7DBF4
SCHEMBL28797209 0.85 BCAT2 (0.50) KDM4ERORBCDC7DBF4RORC
SCHEMBL25779061 0.85 CDC7 (0.50) KDM4EPKMRORBCDC7DBF4
SCHEMBL4524146 0.85 KDM4E (0.46) KDM4EPKMRORBRORCSMN1; SMN2
SCHEMBL24508647 0.84 KDM4E (0.46) KDM4EPKMLMNADHODH
SCHEMBL14711219 0.84 KDM4E (0.46) KDM4EPKMRORBCDC7DBF4
SCHEMBL14564467 0.84 KDM4E (0.55) KDM4EPKMSMN1; SMN2LMNAGAA
SCHEMBL5011865 0.83 KDM4E (0.61) KDM4EPKMRORBL3MBTL1
SCHEMBL13494111 0.83 RORB (0.50) KDM4EPKMRORBRORCL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023118434-A1 PESTICIDALLY ACTIVE AMIDE COMPOUNDS GLOBACHEM NV (BE) 2023-06-29 — — WO disclosed
WO-2023118434-A1 PESTICIDALLY ACTIVE AMIDE COMPOUNDS GLOBACHEM NV (BE) 2023-06-29 — — WO disclosed
EP-3277678-B1 COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS NANTBIO INC (US) 2020-03-18 — — EP disclosed
EP-3232788-B1 TRIAZOLES DERIVATIVES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2019-06-12 — — EP disclosed
US-20180086752-A1 COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS NANTBIO, INC. 2018-03-29 — — US disclosed
CN-107835812-A Target mutant K RAS composition and method 南特生物科学股份有限公司 2018-03-23 — — CN disclosed
EP-3277678-A1 COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS NantBioScience, Inc. (US) 2018-02-07 — — EP disclosed
US-20170360045-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO CORTEVA AGRISCIENCE LLC 2017-12-21 — — US disclosed
WO-2016161361-A1 COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS NANTBIOSCIENCE, INC. (US) 2016-10-06 — — WO disclosed
US-9265769-B2 Thiazolyl- and oxazolyl-isoquinolinones and methods for using them Pellicciari, Roberto (IT) 2016-02-23 — — US disclosed
CN-101506199-A Azetidine compounds as orexin receptor antagonists ACTELION PHARMACEUTICALS LTD (CH) 2009-08-12 — — CN disclosed
EP-2069332-A2 AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS Actelion Pharmaceuticals Ltd. (CH) 2009-06-17 — — EP disclosed
CN-101415704-A 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors HOFFMANN LA ROCHE (CH) 2009-04-22 — — CN disclosed
CN-101415704-A 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors HOFFMANN LA ROCHE (CH) 2009-04-22 — — CN disclosed
EP-1991543-A1 4-PHENYL-THIAZOLE-5-CARBOXYLIC ACIDS AND 4-PHENYL-THIAZOLE-5-CARBOXYLIC ACID AMIDES AS PLK1 INHIBITORS F. Hoffmann-La Roche AG (CH) 2008-11-19 — — EP disclosed
CN-101304985-A Thiazole compounds and their use as PGDs2AntagonistsUse of ARGENTA DISCOVERY LTD (GB) 2008-11-12 — — CN disclosed
WO-2008065626-A2 3-HETEROARYL (AMINO OR AMIDO)-1- (BIPHENYL OR PHENYLTHIAZOLYL) CARBONYLPIPERIDINE DERIVATIVESAS OREXIN RECEPTOR INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2008-06-05 — — WO disclosed
WO-2008020405-A2 AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2008-02-21 — — WO disclosed
WO-2007096315-A1 4-PHENYL-THIAZOLE-5-CARBOXYLIC ACIDS AND 4-PHENYL-THIAZOLE-5-CARBOXYLIC ACID AMIDES AS PLK1 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2007-08-30 — — WO disclosed
US-20050014765-A1 Aryl-heteroaromatic products, compositions comprising them and use AVENTIS PHARMA S.A. (FR) 2005-01-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050014765-A1 Aryl-heteroaromatic products, compositions comprising them and use AHR, ARNT, MYC KDM4E 1246/4885PKM 3447/4885RORB 53/4885
US-20180086752-A1 COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS KRAS, NRAS, HRAS KDM4E 3378/4885PKM 3695/4885RORB 2321/4885
US-20170360045-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO ACHE, DDT, MSMO1 KDM4E 1908/4885PKM 418/4885RORB 2829/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.