Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013488 | 0.76 | KDM1A (0.30) | KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL1222086 | 0.67 | EDNRA (0.33) | CACNA1D | |
| SCHEMBL6694686 | 0.64 | CACNA1D (0.30) | CACNA1D | |
| SCHEMBL4178861 | 0.60 | PPARG (0.35) | — | |
| SCHEMBL6679649 | 0.59 | CACNA1D (0.35) | ALDH1A1CACNA1DPOLB | |
| SCHEMBL9842403 | 0.58 | ELANE (0.33) | — | |
| SCHEMBL9842547 | 0.58 | CACNA1D (0.33) | CACNA1D | |
| SCHEMBL6682470 | 0.58 | TSHR (0.36) | KDM4EMEN1ALDH1A1KMT2ACACNA1D | |
| SCHEMBL8393880 | 0.57 | CACNA1D (0.30) | CACNA1D | |
| SCHEMBL16534046 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | disclosed |