Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 11/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012082 | 0.92 | ADORA1 (0.48) | ADORA1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5012222 | 0.90 | ADORA1 (0.62) | ADORA1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5008418 | 0.88 | GFER (0.60) | ADORA1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5007802 | 0.88 | ADORA1 (0.49) | ADORA1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL27637095 | 0.87 | ADORA1 (0.51) | ADORA1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5010696 | 0.87 | ADORA1 (0.54) | ADORA1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5008686 | 0.86 | ADORA1 (0.49) | ADORA1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5007787 | 0.83 | ADORA1 (0.52) | ADORA1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL14600243 | 0.82 | GFER (0.53) | ADORA1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5005583 | 0.82 | GFER (0.53) | MAPK14MAPK12MAPK13MAPK11GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064734-A1 | Anilinopyrazole derivatives useful for the treatment of diabetes | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-03-13 | — | — | US | claimed |
| US-7265144-B2 | Anilinopyrazole derivatives useful for the treatment of diabetes | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-09-04 | — | — | US | claimed |
| US-20040157904-A1 | Anilinopyrazole derivatives useful for the treatment of diabetes | BAYER PHARMACEUTICALS CORPORATION | 2004-08-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064734-A1 | Anilinopyrazole derivatives useful for the treatment of diabetes | IAPP, GLP1R, GPR119 | ADORA1 749/4885MAPK14 1938/4885MAPK12 1488/4885 |
| US-20040157904-A1 | Anilinopyrazole derivatives useful for the treatment of diabetes | IAPP, GLP1R, GPR119 | ADORA1 749/4885MAPK14 1938/4885MAPK12 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.