Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012967 | 0.92 | KMT2A (0.42) | KMT2ANPC1RAB9ANPSR1 | |
| SCHEMBL16175746 | 0.92 | KDM4E (0.42) | KMT2ANPC1RAB9ANPSR1CHRM3 | |
| SCHEMBL5012846 | 0.91 | CHRM3 (0.39) | KMT2ANPC1RAB9ANPSR1TRPV1 | |
| SCHEMBL5014399 | 0.90 | CHRM3 (0.39) | GPR119KMT2ANPC1RAB9ANPSR1 | |
| SCHEMBL5015815 | 0.89 | RAB9A (0.46) | KMT2ANPC1RAB9ANPSR1 | |
| SCHEMBL5012237 | 0.88 | KMT2A (0.43) | KMT2ANPC1RAB9ACHRNB4CHRNA3 | |
| SCHEMBL16175673 | 0.88 | KMT2A (0.45) | KMT2A | |
| SCHEMBL16175735 | 0.88 | KMT2A (0.43) | KMT2ACHRM2CHRM1CHRM3CHRNB4 | |
| SCHEMBL5012868 | 0.87 | KMT2A (0.40) | KMT2ATRPV1 | |
| SCHEMBL5012860 | 0.86 | HTT (0.41) | KMT2ACHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |