Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16175727 | 0.94 | KMT2A (0.41) | KMT2AMEN1GAAATMPOLB | |
| SCHEMBL16175752 | 0.92 | KMT2A (0.42) | KMT2AMEN1GAAATM | |
| SCHEMBL16175697 | 0.90 | TRPM8 (0.39) | KMT2AMEN1GAAATML3MBTL1 | |
| SCHEMBL16175602 | 0.90 | ATM (0.43) | KMT2AMEN1GAAATMMAPT | |
| SCHEMBL16175733 | 0.89 | LMNA (0.45) | KMT2AMEN1GAAPOLBMAPT | |
| SCHEMBL5012219 | 0.88 | GPR119 (0.40) | KMT2A | |
| SCHEMBL16175735 | 0.88 | KMT2A (0.43) | KMT2APOLBL3MBTL1 | |
| SCHEMBL5012237 | 0.88 | KMT2A (0.43) | KMT2APOLBACHE | |
| SCHEMBL5014461 | 0.86 | ALDH1A1 (0.42) | KMT2AMEN1POLBMAPTKDM4E | |
| SCHEMBL5012860 | 0.86 | HTT (0.41) | KMT2AATMPOLBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |