Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.65 |
| ▸ | HPGD | P15428 | 8/20 | 0.65 |
| ▸ | GAA | P10253 | 5/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | STAT6 | P42226 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051819 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1HPGDGAAHIF1A | |
| SCHEMBL5011522 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1HPGDGAAHIF1A | |
| SCHEMBL4707526 | 0.77 | KDM4E (0.49) | KDM4EALDH1A1HPGDGAAHIF1A | |
| SCHEMBL16222488 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1HPGDGAAHIF1A | |
| SCHEMBL16222483 | 0.69 | KDM4E (0.55) | KDM4EALDH1A1HPGDGAAHIF1A | |
| SCHEMBL16222484 | 0.69 | ALDH1A1 (0.75) | KDM4EALDH1A1HPGDHIF1ALMNA | |
| SCHEMBL5013088 | 0.68 | KDM4E (0.55) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL4923976 | 0.68 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDGAAHIF1A | |
| SCHEMBL5013044 | 0.68 | ALDH1A1 (0.71) | KDM4EALDH1A1HPGDGAAHIF1A | |
| SCHEMBL16222482 | 0.67 | NPSR1 (0.85) | KDM4EALDH1A1HPGDHIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207645-A1 | Pyridothienopyrimidine Derivatives | PAGES SANTACANA LUIS MIGUEL | 2008-08-28 | — | — | US | disclosed |
| EP-1819712-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | Laboratorios Almirall, S.A. (ES) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006058723-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207645-A1 | Pyridothienopyrimidine Derivatives | PDE4A, PDE5A, PDE3B | KDM4E 1526/4885ALDH1A1 438/4885HPGD 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.