Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.52 |
| ▸ | HPGD | P15428 | 8/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013044 | 0.78 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL5012401 | 0.77 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL4922970 | 0.74 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL16222483 | 0.72 | KDM4E (0.55) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL5011522 | 0.69 | KDM4E (0.54) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL5012355 | 0.68 | KDM4E (0.65) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL4711632 | 0.68 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL14306176 | 0.65 | IDH1 (0.52) | ALDH1A1KDM4EHPGDGAAHIF1A | |
| SCHEMBL31647644 | 0.62 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL15877274 | 0.62 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221096-A1 | Pyrido[3' ,2':4,5]Furo[3,2-d]Pyrimidine Derivatives | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-09-11 | — | — | US | disclosed |
| US-20080207645-A1 | Pyridothienopyrimidine Derivatives | PAGES SANTACANA LUIS MIGUEL | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207645-A1 | Pyridothienopyrimidine Derivatives | PDE4A, PDE5A, PDE3B | ALDH1A1 438/4885KDM4E 1526/4885HPGD 25/4885 |
| US-20080221096-A1 | Pyrido[3' ,2':4,5]Furo[3,2-d]Pyrimidine Derivatives | NR1H2, CBR3, NR4A1 | ALDH1A1 2625/4885KDM4E 3618/4885HPGD 1978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.