Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.38 |
| ▸ | ATM | Q13315 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012278 | 0.92 | KMT2A (0.39) | KMT2AMEN1ALDH1A1POLBTDP1 | |
| SCHEMBL5014484 | 0.92 | ALDH1A1 (0.41) | KMT2AALDH1A1POLBTDP1ATM | |
| SCHEMBL5012284 | 0.90 | MAPT (0.42) | KMT2AMEN1POLBTDP1ATM | |
| SCHEMBL5012775 | 0.90 | CA1 (0.41) | KMT2APOLBTDP1ATMMAPT | |
| SCHEMBL5011200 | 0.90 | CA1 (0.40) | ALDH1A1POLBTDP1ATMMAPT | |
| SCHEMBL16175601 | 0.90 | HTT (0.44) | KMT2AALDH1A1POLBTDP1ATM | |
| SCHEMBL5014531 | 0.90 | FAAH (0.41) | KMT2APOLBTDP1CTDSP1APAF1 | |
| SCHEMBL5012924 | 0.90 | GRIN2B (0.42) | KMT2AMEN1ALDH1A1POLBTDP1 | |
| SCHEMBL5012726 | 0.90 | MAPT (0.47) | KMT2AMEN1POLBTDP1MAPT | |
| SCHEMBL5011290 | 0.89 | POLB (0.43) | POLBTDP1ATMMAPTCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |