Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GPX4 | P36969 | 4/20 | 0.53 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.51 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 2/20 | 0.51 |
| ▸ | FNTB | P49356 | 2/20 | 0.51 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1863115 | 0.82 | POLB (0.63) | NPSR1MEN1MAPK1KMT2APOLB | |
| SCHEMBL5013045 | 0.80 | ALDH1A1 (0.57) | NPSR1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1976542 | 0.78 | POLB (0.65) | KMT2APOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL31350860 | 0.78 | CYP3A4 (0.69) | CYP3A4CYP3A5MEN1MAPK1KMT2A | |
| SCHEMBL1865263 | 0.77 | POLB (0.63) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL31351144 | 0.76 | NPSR1 (0.69) | NPSR1MEN1MAPK1KMT2AMAPT | |
| SCHEMBL13149251 | 0.76 | ALDH1A1 (0.68) | CYP3A4MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL2002157 | 0.76 | POLB (0.61) | KMT2APOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3764825 | 0.75 | POLB (0.61) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL14459989 | 0.74 | POLB (0.60) | MEN1KMT2APOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306087-A1 | Therapeutic Agents | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | claimed |
| US-20080306087-A1 | Therapeutic Agents | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | disclosed |
| US-20080306087-A1 | Therapeutic Agents | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | disclosed |
| US-20080306087-A1 | Therapeutic Agents | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | disclosed |
| WO-2007018459-A1 | THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306087-A1 | Therapeutic Agents | NLN, BDNF, GAP43 | CYP3A4 2910/4885CYP3A5 1913/4885NPSR1 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.