⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4146411 | 0.56 | — | — | |
| SCHEMBL585661 | 0.54 | — | — | |
| Hydrochloric Acid SCHEMBL7938304 | 0.45 | — | — | |
| SCHEMBL23774760 | 0.44 | — | — | |
| Hydrochloric Acid SCHEMBL1651795 | 0.34 | — | — | |
| Hydrochloric Acid SCHEMBL4441523 | 0.28 | — | — | |
| SCHEMBL1055696 | 0.28 | — | — | |
| Hydrochloric Acid SCHEMBL7893683 | 0.28 | — | — | |
| Hydrochloric Acid SCHEMBL2031841 | 0.28 | CYP3A4 (0.33) | — | |
| Hydrochloric Acid SCHEMBL19132 | 0.28 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1193219-A | — | — | None | — | — | JP | disclosed |
| EP-1383774-B1 | DIHYDROIMIDAZO¬4,5-E INDOLE AND 7H-PYRROLO¬3,2-F QUINOXALINE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2008-05-07 | — | — | EP | disclosed |
| US-7279496-B2 | Dihydroimidazo[4,5-e]indole and 7h-pyrrolo[3,2-f]quinoxaline derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2007-10-09 | — | — | US | disclosed |
| US-7279496-B2 | Dihydroimidazo[4,5-e]indole and 7h-pyrrolo[3,2-f]quinoxaline derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2007-10-09 | — | — | US | disclosed |
| EP-1513839-B1 | 3-SUBSTITUTED QUINUCLIDINES AND THEIR USE | NEUROSEARCH AS (DK) | 2006-07-26 | — | — | EP | disclosed |
| US-20040142935-A1 | Dihydroimidazo[4,5-e]indole and 7h-pyrrolo[3,2-f]quinoxaline derivatives as nicotinic acetylcholine receptor liqands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2004-07-22 | — | — | US | disclosed |
| US-20040142935-A1 | Dihydroimidazo[4,5-e]indole and 7h-pyrrolo[3,2-f]quinoxaline derivatives as nicotinic acetylcholine receptor liqands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2004-07-22 | — | — | US | disclosed |
| EP-1383774-A2 | DIHYDROIMIDAZO[4,5-E]INDOLE AND 7H-PYRROLO[3,2-F]QUINOXALINE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GmbH (DE) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002088143-A2 | DIHYDROIMIDAZO[4,5-E]INDOLE AND 7H-PYRROLO[3,2-F]QUINOXALINE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2002-11-07 | — | — | WO | disclosed |
| JP-H01193219-A | DRUG HAVING ERYTHROCYTE COAGULATION PREVENTING ACTION | BOEHRINGER MANNHEIM GMBH | 1989-08-03 | — | — | JP | disclosed |