Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.64 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16212516 | 0.96 | NAMPT (0.71) | NAMPTHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL16212712 | 0.96 | NAMPT (0.71) | NAMPTHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL16212722 | 0.96 | NAMPT (0.71) | NAMPTHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL16212709 | 0.87 | NAMPT (0.83) | NAMPTHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL16212873 | 0.87 | NAMPT (0.83) | NAMPTHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL13749827 | 0.86 | NAMPT (0.69) | NAMPTHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL25002736 | 0.85 | NAMPT (0.71) | NAMPTHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL16212558 | 0.85 | NAMPT (0.71) | NAMPTHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL16213049 | 0.85 | NAMPT (0.71) | NAMPTHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL16212713 | 0.85 | NAMPT (0.75) | NAMPTHDAC3HDAC1HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419962-B2 | 3,6-bicyclolides | ENANTA PHARMACEUTICALS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| EP-1830858-A2 | 3, 6-BICYCLOLIDES | Enanta Pharmaceuticals, Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| US-7229972-B2 | Semisynthetic trimethylenedioxy-erythromycin derivatives and their use in treating bacterial infections and cystic fibrosis; preparation | ENANTA PHARMACEUTICALS, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-20060142214-A1 | 3,6-bicyclolides | ENANTA PHARMACEUTICALS, INC. | 2006-06-29 | — | — | US | disclosed |
| WO-2006063039-A2 | 3, 6-BICYCLOLIDES | ENANTA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |
| US-20060122128-A1 | 3,6-Bicyclolides | ENANTA PHARMACEUTICALS, INC. | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122128-A1 | 3,6-Bicyclolides | ABCB11, CYP2B6, CYP3A7 | NAMPT 1667/4885HDAC3 470/4885HDAC1 1200/4885 |
| US-20060142214-A1 | 3,6-bicyclolides | ABCB11, CYP2B6, CYP3A7 | NAMPT 1667/4885HDAC3 470/4885HDAC1 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.