Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 10/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5479510 | 0.78 | POLB (0.38) | POLBUSP2SMN1; SMN2NPSR1CACNA1D | |
| SCHEMBL6808142 | 0.75 | POLB (0.36) | POLBUSP2SMN1; SMN2NPSR1CYP2C19 | |
| SCHEMBL6293052 | 0.74 | FABP7 (0.34) | POLBUSP2SMN1; SMN2 | |
| SCHEMBL6709305 | 0.73 | EDNRA (0.34) | RIPK1CYP2C19 | |
| SCHEMBL8501778 | 0.73 | NR4A2 (0.34) | RIPK1L3MBTL1SMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL6903843 | 0.72 | POLB (0.36) | POLBUSP2SMN1; SMN2NPSR1CYP2C9 | |
| SCHEMBL10715608 | 0.71 | SMN1; SMN2 (0.41) | POLBUSP2SMN1; SMN2NPSR1CYP2C19 | |
| SCHEMBL4371618 | 0.70 | SLC9A1 (0.36) | POLBUSP2SMN1; SMN2NPSR1CYP2C19 | |
| SCHEMBL7184223 | 0.70 | POLB (0.37) | POLBUSP2SMN1; SMN2NPSR1 | |
| SCHEMBL8525874 | 0.70 | NR4A2 (0.32) | RIPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | disclosed |