Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 2/20 | 0.46 |
| ▸ | ARG2 | P78540 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | ODC1 | P11926 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1915859 | 0.85 | ARG1 (0.37) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL1916739 | 0.80 | ARG1 (0.34) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL5004419 | 0.79 | ARG1 (0.51) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL14764492 | 0.79 | ARG1 (0.33) | ARG1ARG2ODC1 | |
| SCHEMBL1916171 | 0.78 | TSHR (0.33) | ARG1ARG2ODC1KDM4ELMNA | |
| SCHEMBL16728201 | 0.75 | ARG1 (0.31) | ARG1ARG2 | |
| SCHEMBL8714547 | 0.75 | CYP2D6 (0.41) | CYP1A2CYP2D6SMN1; SMN2GRM2GRM3 | |
| SCHEMBL2419413 | 0.75 | SLC1A3 (0.31) | ARG1ARG2ODC1 | |
| SCHEMBL2129918 | 0.75 | ARG1 (0.50) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL1515330 | 0.75 | ARG1 (0.50) | ARG1ARG2NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |